At least 57 people were dead in US-led air strikes on Islamic State prison in eastern Syria on Tuesday.
The UK-based Syrian Observatory for Human Rights said the air strike took place on Monday at dawn, hitting a building in the town of Mayadin, south of Raqqa, that was being used as a prison.
"The strikes hit an IS jail in Mayadin at dawn on Monday,
killing 42 prisoners and 15 jihadists," Observatory chief Rami Abdel Rahman told AFP.
Many of the dead are thought to be civilians, as well as captured rebel fighters from the Free Syrian Army.
If the toll is confirmed, it would make it one of the deadliest single incidents since the US intervened in the Syrian war in 2014.